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    Improving patient care through objective detection and monitoring for acute encephalopathy and delirium

    DeltaScan revolutionises patient care

    The development of DeltaScan was initiated by clinicians with the aim to improve patient recovery by detecting acute encephalopathy and delirium more often and earlier. Better recognition is beneficial not only for patients and their relatives, but also for clinicians and budget holders. Guidelines prescribe that patients with an increased risk of delirium should be monitored at least once per shift.

    We developed Prolira-DeltaScan to detect acute encephalopathy and delirium more frequently and earlier. Our goal is to improve the quality of care, as better detection of delirium leads to better patient outcomes, shorter hospital stays and a reduction in healthcare costs. DeltaScan is an objective medical device that works on the basis of 1-channel EEG signal (Electroencephalography). EEG has proven to be a biomarker for delirium (Source: Van der Kooi et al., 2015, Chest) and acute encephalopathy (Source: Hut et al., 2021, Psychiatry Clin Neurosci.). The result (Score) of DeltaScan is a parameter for acute encephalopathy and delirium.

    The 1-channel EEG, made by DeltaScan, clearly shows a difference between a patients with delirium and patient without delirium (Source: Van der Kooi et al., 2015, Chest). Delirium is characterized by strong and strongly slowed waves in an EEG (Source: Van der Kooi et al., 2015, Chest / Kimchi et al., 2019, Neurology).

    These waves are called polymorphic Delta waves (Figure 1). When there is no delirium, these waves don’t present themselves (Figure 2).


    Photo: Erasmus MC

    Diederik Gommers:
    ‘Without investing in innovations
    you further undermine healthcare’

    The coronavirus crisis has shown that the way in which we design our healthcare system will have to change drastically, says IC head Diederik Gommers. An important role in this process is laid out for medical innovations.

    Photo: Joppe Jansen

    Patient story Joppe Janssen:
    ‘All in all, the delirium lasted three days without the doctors or nurses noticing any of it. Isn’t it strange, the way things can happen with a quiet delirium?’

    After New Year’s Eve my throat started bothering me. I had difficulty swallowing, it felt like flu, I had a fever. I thought I just had a regular winter flu. My GP gave me antibiotics for a throat infection, and then I did what everyone does: I crawled into bed to ride it out.

    Foto: Hanneke Oonk

    Hanneke Oonk:
    ‘I would therefore recommend that ICUs should also have a policy to identify a delirium as quickly as possible so that the treatment can be adjusted accordingly.

    I see the bulk of my patients a year or perhaps many years after they have been discharged from the hospital. All the attention essentially goes to the physical recovery. This can be at a rehabilitation centre, or at home assisted by physiotherapists or occupational therapists, but the fact remains that the body is central, and the mental aspects are overshadowed.

    Foto: Dr. Thomas Ottens

    Dr. Thomas Ottens:
    ‘I am convinced that implementing routine delirium screening is feasible for every ICU in the Netherlands. We must do everything we can to minimise the consequences of delirium.’

    In the intensive care unit, we often encounter delirium. That is due to the type of patients we treat. People in the IC unit have a greater than average chance of developing delirium. They are very ill patients who often have cardiac failure or sepsis or have undergone major surgery.


    Medical device based on EEG

    EEG (ElectroEncephaloGram) is the depiction of the electrical activity in the brain. As acute encephalopathy and delirium are forms of acute failure of the brain, DeltaScan is a practical device for detection & monitoring for delirium and acute encephalopathy in patients. DeltaScan can be used by healthcare professionals (nurses and doctors) at the patient’s bedside. The patient’s brain activity is rapidly measured and DeltaScan detects and quantifies those specific waveshape patterns in the EEG, that are characteristic for acute encephalopathy and delirium (also called polymophic Delta waves, PMD).

    EEG without delirium

    EEG with delirium


    Are you interested, or do you have any questions?

    Please contact us!






      E-learning

      We offer 3 free e-learning modules, each of about 10 minutes, that
      are informative and interactive, partly because they contain videos: 

      1. for nurses: delirium and acute encephalopathy
      2. for doctors: delirium
      3. for healthcare professionals: Prolira-DeltaScan use

      or contact our Account Managers

      Delirium detection and monitoring

      Compared to current subjective screening methods for delirium, DeltaScan aims to improve the “patient journey” of patients at risk of delirium.


      How to use DeltaScan

      This short video explains how to use DeltaScan.


      Are you interested, or do you have any questions?

      Please contact us!






        DeltaScan® is an EU registered trademark (Certificate Nr 018280613)

        Prolira BV
        Padualaan 8
        3584 CH Utrecht
        The Netherlands


        T.
        E.W.


        +31 (0)85 060 1656
        info@prolira.com
        www.prolira.com